OK, for the sake of argument let’s assume that having a BMI of 25-29.9 is not detrimental to one’s health as compared to those of BMI 18.5 to 25. Let’s assume that for anyone of normal or overweight that a day or two of fasting a month will provide the same effects as resveratrol: caloric restriction basically gives the cells a rest (to vastly oversimplify).

Using an appetite suppressant for caloric restriction seems to be a shortcut, is my point.

Actually, my point was really that Glaxo overpaid because I bet you can get the resveratrol effects by caloric restriction (overlapping transcripts and all).

* Underweight individuals (BMI of less than 18.5) had a higher risk of death with nearly 34,000 more deaths than expected.

* Being overweight (BMI of 25-29.9) was not associated with excess mortality. The study found that 87,000 fewer deaths than expected were associated with being overweight.

http://www.cdc.gov/od/oc/media/pressrel/fs050419.htm