Alzheimer's

Obesity research: Tesofensine and NS2359 drug family for weight loss - Better to block three receptors than only 5HT2c? Nah.

Friday, May 30th, 2008

So far, lorcaserin is the only weight loss drug in the near future that makes commercial sense to me, not to say it is the most wonderful drug in the world and the science is, imo, sort of a yawner.
I keep an eye out for better weight loss drugs on the horizon — so here’s [...]

DNA Research Roundup: Fragile X Premutation, Schizophrenia, Bipolar Disorder and Major Psychosis all related to DNA misprocessing

Thursday, May 29th, 2008

Albert Bierstadt, Lake Tahoe, Spearfishing by Torchlight (1867)
I’ve wondered why the meanest relatives live the longest , and pointed to some DNA trinuclotide repeat disorders that have psychiatric aspects — like machiavellianism or just meanness . So here’s more on that: Fragile X premutation, schizophrenia, biopolar and major psychosis are all related to [...]

Genetics: 200 family members having dementia-mutation studied for 13 years

Wednesday, January 16th, 2008

Brain. 2008 Jan;131(Pt 1):72-89. Epub 2007 Dec 7., “The tauopathy associated with mutation +3 in intron 10 of Tau: characterization of the MSTD family,” Spina S, Farlow MR, Unverzagt FW, Kareken DA, Murrell JR, Fraser G, Epperson F,Crowther RA, Spillantini MG, Goedert M, Ghetti B., Department of Pathology and Laboratory Medicine, Indiana University School [...]

Cure for Alzheimers?

Thursday, January 10th, 2008

Let’s say the day comes when you are told you have pre-Alzheimers. You are told that getting the disease is inevitable. Emotionally, you grieve for your own “lost” personality. Your loved ones prepare for your care taking — or to put you in assisted living at an outrageous expense to someone.
Then this report [...]

Neurological Correlates: Apathy

Saturday, September 29th, 2007

Clin Neurol Neurosurg. 2007 Sep 25; [Epub ahead of print]

Striatal dopamine transporter levels correlate with apathy in neurodegenerative diseases A SPECT study with partial volume effect correction.
David R, Koulibaly M, Benoit M, Garcia R, Caci H, Darcourt J, Robert P.
Centre Mémoire de Ressource et de Recherche, CHU Nice, France.
OBJECTIVES: The aim of the [...]